Innovative Technologies
Synthetic glycoproteins, glycopeptides, glycopolymers, glycolipids, glycoheterocycles, glycoaminoacids and combinations thereof.
Carbohydrate nanotechnology: integration of glycans and nanomaterials
Glycoworld has synthesized and studied carbohydrate molecules to determine their utility in biosensing and electroanalytical applications.
In collaboration with Professor Keith Stine (UMSL) we studied the application of porous nanostructured materials to the supported synthesis of glycans. We have also investigated the application of porous nanomaterials to detecting carbohydrate-protein interactions by electrochemical and spectroscopic means.
Other applications of nanoporous gold material include separation, enrichment, and biosensing of glycoproteins.
J. K. Bhattarai, D. Neupane, B. Nepal, A. V. Demchenko, and K. J. Stine. Nanoporous gold monolith for high loading of unmodified doxorubicin and sustained co-release of Doxorubicin-Rapamycin. Nanomaterials, 2021, 11, 208 PMID: 33467416 (2R01-13) |
D. Neupane, J. K. Bhattarai, A. V. Demchenko, and K. J. Stine. A pH-sensitive thiolated β-cyclodextrin-modified nanoporous gold for controlled release of doxorubicin. J. Drug Deliv. Sci. Technol., 2020, 101985
PMID: 32922527 (2R01-8, U01-24)
J. Bhattarai, D. Neupane, B. Nepal, M. D. Alharthi, A. V. Demchenko, and K. J. Stine. Adhesion layer-free attachment of gold on silicon wafer and its application in localized surface plasmon resonance-based biosensing. Sens. Actuators A: Phys., 2020, 312, 112155
PMID: 32647405 (2R01-5)
Other projects: metal complexes, thermochemical, and theoretical studies
Glycoworld has been involved in several other collaborative and individual projects that span across a few research areas including metal complexes with carbohydrates and thermochemical studies.
S. Escopy, Y. Singh, and A. V. Demchenko. Palladium(II)-assisted activation of thioglycosides. Org. Biomol. Chem., 2021, 19, 2044-2054
PMID: 33599667 (2R01-14, 3NSF-21)
M. Panza, M. Civera, J. P. Yasomanee, L. Belvisi, and A. V. Demchenko. Bromine-promoted glycosidation of conformationally superarmed thioglycosides. Chem. Eur. J., 2019, 25, 11831-11836
PMID: 31286579 (U01-15, 3NSF-6)
J. P. Yasomanee, A. R. Parameswar, P. Pornsuriyasak, N. P. Rath, A. V. Demchenko. 2,3-Di-O-picolinyl building blocks as glycosyl donors with switchable stereoselectivity. Org. Biomol. Chem., 2016, 14, 3159–3169
PMID: 26911322 (2NSF-19, Mizu-4)
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